Mechanism Of Action: Sulfadoxine is an ultra-long-lasting sulfonamide used in combination with pyrimethamine an antiparasitic agent, to treat malaria.
Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis. Pyrimethamine interferes with the regeneration of tetrahydrofolic acid from dihydrofolate by competitively inhibiting the enzyme dihydrofolate reductase. Tetrahydrofolic acid is essential for DNA and RNA synthesis in many species, including protozoa.
Dose:
By weight: 5-10kg- ½ tablet; 11-20kg- 1 tablet; 21-30kg- 1 ½ tablet; 31-45kg- 2 tablets; > 45kg: 3 tablets.
Drug Formulation: Tablet
Quantity Per Pack: 3 Tablets
Place Of Production: Swiss Pharma Nigeria Ltd
Marketing Company: SWIPHA
Nafdac No: A4- 6639
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